Production of cartilage oligomeric matrix protein (COMP) by cultured human dermal and synovial fibroblasts
نویسندگان
چکیده
منابع مشابه
Analysis of cartilage oligomeric matrix protein (COMP) in synovial fibroblasts and synovial fluids.
We investigated the expression of cartilage oligomeric matrix protein (COMP) in normal and rheumatoid arthritis (RA) synovial fibroblasts. In situ hybridization (ISH) was conducted on synovial specimens from five RA patients applying specific probes for COMP or fibroblast collagen type I. ISH was combined with immunohistochemistry, applying antibodies to the macrophage marker CD68. Ribonuclease...
متن کاملCartilage Oligomeric Matrix Protein (COMP): A Biomarker of Arthritis
Arthritis is a chronic disease with a significant impact on the population. It damages the cartilage, synovium, and bone of the joints causing pain, impairment, and disability in patients. Current methods for diagnosis of and monitoring the disease are only able to detect clinical manifestations of arthritis late in the process. However, with the recent onset of successful treatments for rheuma...
متن کاملGalectin-3 is induced in rheumatoid arthritis synovial fibroblasts after adhesion to cartilage oligomeric matrix protein.
BACKGROUND Galectin-3 is expressed in the synovial tissue of patients with rheumatoid arthritis (RA), particularly at sites of joint destruction. OBJECTIVE To explore the possibilities that galectin-3 is induced either by proinflammatory cytokines or by adhesion to cartilage components. METHODS Cell culture plates were coated with fibronectin, collagens I-VI, or cartilage oligomeric matrix ...
متن کاملThyroid hormones increase collagen I and cartilage oligomeric matrix protein (COMP) expression in vitro human tenocytes.
BACKGROUND we previously demonstrated the presence of high levels of thyroid hormones (THs) receptors isoforms in healthy tendons, their protective action during tenocyte apoptosis, and the capability to enhance tenocyte proliferation in vitro. In the present study we tested the ability of THs to influence ECM protein tenocyte secretion in an in vitro system. METHODS primary tenocyte-like cel...
متن کاملCartilage Oligomeric Matrix Protein (COMP) and Hyaluronic Acid (HA): Diagnostic Biomarkers of Knee Osteoarthritis
Osteoarthritis (OA), leads to considerable morbidity and disability in elderly [1]. The condition is diagnosed basically on clinical presentation and radiographic findings. By the time changes are visible on radiographs the disease is fairly advanced. Radiographic changes are apparent only after a year or two, but changes in biomarker levels are apparent within a few months [2]. Biomarkers are ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 1998
ISSN: 1063-4584
DOI: 10.1053/joca.1998.0147